High Containment Sampling System
Introduction
Handling highly potent powders requires more than accurate sampling. It demands a solution that protects operators, preserves product integrity and minimizes the risk of contamination.
The FAMAT 125TC/OEL High Containment Sampling System has been specifically developed for pharmaceutical, HPAPI and other high-value powder applications requiring contained sampling. Combining the patented EPT® Expanding Piston Technology (EPT®) with an active/passive split butterfly valve, it enables representative sampling while maintaining a closed transfer path between the process and the sampling bottle.
Watch the video below to discover how the 125TC/OEL ensures safe and reliable high-containment sampling.
What is the 125TC/OEL High Containment Sampling System?
The 125TC/OEL is a compact high-containment sampling solution designed for processes where operator protection and product containment are essential.
The system allows the sampling bottle to be connected and removed under contained conditions, significantly reducing operator exposure while ensuring representative powder sampling. Its hygienic design and compatibility with CIP/SIP procedures make it ideal for GMP manufacturing environments.
Key Features & Benefits
- High-containment split butterfly valve system
- Active/passive module design
- Bottle removal under contained conditions
- Hygienic and fully drainable product-contact area
- Suitable for high-potency and aseptic applications
- Compatible with CIP/SIP processes
- OEB level: 1-10 μg/m³ without aspiration
- OEB level: <1 μg/m³ with aspiration
How the High Containment System Works
The integrated containment system ensures safe sampling while maintaining product and operator protection throughout the entire sampling cycle.
1. Connect the sampling bottle
The bottle is attached to the passive split butterfly valve under contained conditions.
2. Perform representative sampling
The patented EPT® Expanding Piston Technology collects a representative sample while maintaining process integrity.
3. Close the valve
The split butterfly valve isolates the product before bottle removal.
4. Remove the bottle safely
The bottle can be disconnected while maintaining containment, minimizing operator exposure and environmental contamination.
Why Choose the 125TC/OEL?
Unlike conventional sampling systems, the 125TC/OEL combines representative sampling with high containment in a single compact solution.
It helps manufacturers:
- Protect operators from hazardous powders
- Reduce the risk of cross contamination
- Maintain GMP compliance
- Preserve product integrity
- Simplify contained sample collection
Typical Applications
The 125TC/OEL High Containment Sampling System is ideally suited for:
- HPAPI manufacturing
- Pharmaceutical production
- Fine chemicals
- Potent compounds
- Sterile processing
- Biotechnology
- Contained powder handling
Engineering Insight
High containment is not only about protecting operators. It also preserves product integrity by minimizing environmental exposure and reducing the risk of cross contamination during sampling. Combining EPT® Expanding Piston Technology with a split butterfly valve provides a contained sampling solution suitable for highly potent powders and GMP manufacturing environments.
FAQ
What is a high containment sampling system?
A high containment sampling system allows operators to collect representative samples while minimizing exposure to hazardous powders and preventing product contamination.
Which containment level does the 125TC/OEL achieve?
The system provides containment performance from 1 to 10 μg/m³ without aspiration and can achieve less than 1 μg/m³ when used with aspiration, depending on the installation and operating conditions.
What is the benefit of the split butterfly valve?
The integrated active/passive split butterfly valve allows the sampling bottle to be connected and removed under contained conditions, reducing operator exposure and preventing powder release.
Is the system suitable for HPAPI manufacturing?
Yes. The 125TC/OEL is specifically designed for high-potency compounds, HPAPIs, pharmaceutical manufacturing and other applications requiring high containment.
Can the system be cleaned using CIP or SIP?
Yes. The hygienic product-contact area is compatible with both CIP (Clean-in-Place) and SIP (Sterilize-in-Place) processes.
Does the system provide representative samples?
Yes. The sampling valve incorporates FAMAT’s patented EPT® Expanding Piston Technology, ensuring representative sampling while minimizing contamination risks.
Related Videos
- 125A Standard Sampling Valve – Standard EPT® sampling solution for powders, granules, pastes and liquids.
- 125S Safety Sampling Valve – Mechanical Poka-Yoke system for safer sampling operations.
- 125AUT Automatic Sampling Valve – Pneumatic sampling for automated production lines.
- Continuous Liner System – OEB 5 containment solution for safe powder transfer.
Related White Papers
- High-Containment Sampling for HPAPIs
- Cross Contamination in Industrial Sampling
- Representative Powder Sampling: Principles, Best Practices and Industrial Applications
- How to Select the Right Sampling Valve for Your Process
Related Application Notes
- HPAPI Sampling
- Sterile Powder Sampling
- Pharmaceutical Powder Sampling
- Battery Powder Sampling
